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Quinidine can block IKr at verylow concentrations with resultant action potential prolongationand potential for torsade de pointes that is nondose dependent.Thus, quinidine is best initiated in the hospital.
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Except forIV availability, oxazepam has the same advantages.Chlordiazepoxide (Librium) can be used in young–oldpatients in withdrawal whose hepatic function is intact;in old–old patients and in those with even moderatedegrees of hepatic dysfunction, this drug should beavoided.
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